The impact of circulating regulatory T cells number and their subpopulations on risk of lymph node metastasis

نویسندگان

  • Jerzy Wydmanski
  • Agata Chwieduk
  • Agnieszka Gdowicz-Klosok
  • Magdalena Glowala-Kosinska
  • Tomasz Latusek
  • Agnieszka Namysl-Kaletka
  • Malgorzata Kraszkiewicz
  • Andrzej Tukiendorf
چکیده

Background Regulatory T cells (Tregs) suppress the induction of immune response to cancer cells. An increased number of Tregs have been observed in many solid tumors. The aim of this study was to evaluate whether the number and percentage of circulating Tregs and their subpopulations differ in patients with gastric cancer (GC) and normal controls (NC). The relationship between Tregs subpopulations and clinical factors was analyzed.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Clinicopatholgic Parameters Associated With Regional Lymph Node Metastasis In Oral Squamous Cell Carcinoma: A Retrospective Study

  Background and Objective: Oral cancer accounts for less than 3% of all cancers. Despite recent improvement in diagnostic and treatment methods, the overall survival of the disease is unfavorable. Several studies have been performed to assess factors influencing lymph node metastasis and prognosis. The aim of this study was to evaluate some clinical and pathological factors influencing lymph ...

متن کامل

بررسی اثر تماس مستقیم سلولهایT بکر با سلولهای فیبروبلاست تحریک شده با BCG بر القای سلولهایT تنظیمی

Background: Lymph node stromal fibroblasts are interconnected with TCD4+ cells and affect their phenotype and function. Understanding the nature of these interactions under unusual conditions like infections will help to their application in control and regulation of immune responses. Materials and methods: Lymph node fibroblasts were affected in BCG primed immune environment by both in-...

متن کامل

Significance of histopathological features of breast carcinoma and its correlation for desision of future therapy

Breast cancer is one of the most common malignancies among women and considered as the first caise of mortality in females suffering from malignant processes.axillary lymph node metastasis (ALNM)is the most important predictor of survival in patient with breast carcinoma.the purpose of this study was to determine the association between the incidence of ALNM and morphologic criteria by univaria...

متن کامل

Axillary lymph node metastasis in medullary thyroid carcinoma: A case report

Introduction: Medullary thyroid cancer (MTC) is an uncommon neoplasm originating from parafollicular C cells. Distant metastasis in MTC, such as axillary node involvement, is extremely rare.  Case Report: The present study describes a known case of MTC with axillary lymph node metastasis in a 31-year-old woman. In 2010, she underwent total thyroidectomy and right-sided modified radical neck dis...

متن کامل

Effects of T-2 Toxin on Cytokine Produc-tion by Mice Peritoneal Macrophages and Lymph Node T-Cells

Background: T-2 toxin is a mycotoxin of type A trichothecenes produced by several fungal genera such as Fusarium species. Mycotoxins can affect both cell mediated and humoral immune compartments. Objective: The purpose of this study was to investi-gate the effect of T-2 toxin on cytokine production by mouse peritoneal macrophages and lymph node T cells. Methods: Mouse peritoneal macrophages and...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2015